LabSense

eGFR Low (Decreased Kidney Function): Staging, Causes, and Smart Follow-Up

8/27/2025

eGFR estimates kidney filtration from creatinine (sometimes cystatin C). Searches you’ll see: “eGFR 58”, “borderline kidney function”, “how to improve eGFR”. eGFR varies with age, sex, muscle mass, pregnancy, and acute illness. Trend is more informative than one result.

Staging snapshot (education)

  • G1/G2: eGFR ≥ 60 with other markers (e.g., albuminuria) can still indicate CKD.
  • G3a: 45–59; G3b: 30–44; G4: 15–29; G5: < 15 (advanced).

Educational next steps clinicians consider

  1. Repeat creatinine/eGFR when well-hydrated; add urinalysis and albumin/creatinine ratio (ACR).
  2. Check blood pressure, diabetes control, medication list (NSAIDs, PPIs, contrast exposure), and hydration.
  3. Discuss ACEi/ARB or SGLT2 inhibitor benefits in appropriate patients (per clinician judgement); manage lipids and smoking cessation.
  4. Escalate sooner for eGFR < 30, rapidly declining trend, abnormal potassium or acid-base, or significant albuminuria.

FAQs

Can creatine or heavy workouts lower eGFR?
They can raise serum creatinine and make eGFR look lower; cystatin C–based eGFR can help when muscle mass is atypical.
What diet helps kidney function?
Focus on BP and glucose control, plant-forward meals, moderate sodium, adequate protein (not excessive), and hydration as advised by a clinician.

Educational use only. Not a diagnosis or treatment plan.

Educational information only — not a diagnosis, treatment, or prescription.